Last data update: May 13, 2024. (Total: 46773 publications since 2009)
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Evaluation of performance and acceptability of two rapid oral fluid tests for HIV detection in Mozambique
Sema Baltazar C , Raposo C , Jani IV , Shodell D , Correia D , Goncalves da Silva C , Kalou M , Patel H , Parekh B . J Clin Microbiol 2014 52 (10) 3544-8 Simplified HIV testing based on oral fluid (OF) may allow the expansion of HIV counseling and testing (CT) while reducing the risk due to exposure to sharps and blood collection. This study evaluated the performance and acceptability of two OF tests (OraQuick Advance HIV-1/2 and Chembio DPP HIV-1/2), compared with the national testing algorithm in Mozambique from May to September 2009 in two CT sites in Maputo City. OF testing was conducted in parallel with national HIV algorithm based on whole blood. Blood samples were collected as dried blood spot (DBS) specimens from all participants for quality assurance. HIV results were delivered according to the national algorithm. According to the national HIV algorithm 512 (30.5%) were reactive, 1151 (68.7%) were non-reactive, and 13 (0.8%) were discordant. All discordant cases were re-tested with enzyme immunoassay followed by Western blot, and five (38.5%) were confirmed as HIV positive. OraQuick showed 518 (30.9%) reactive, and 1158 (69.1%) non-reactive, with sensitivity and specificity of 99.8% and 99.8%, respectively. Chembio DPP OF test showed 519 (31.0%) reactive and 1157 (69.0%) non-reactive with sensitivity and specificity of 100% and 99.8%, respectively. Participants perceived blood testing (49.9%) to be more accurate than OF testing (46.8%). OF testing showed high performance for the diagnosis of HIV infection when examined individually as well as in an algorithm, compared with the national testing algorithm. |
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